Jornal de Doenças Tropicais e Saúde Pública

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Worsening Muscle Weakness in Myasthenia Gravis Patient Suffering Dengue Infection

Hardjo Lugito NP, Margaret, Andree Kurniawan and Merlyn Tjiang

The dengue infection is the second most common mosquito-borne disease affecting human beings. Dengue can manifest with a wide range of neurological features, which have been noted - depending on the clinical setting in 0.5-21% of patients with dengue admitted to hospital. Neuromuscular complication can manifest in muscle weakness, which can be found in forms of myalgia, myositis to rhabdomyolysis, Guillain – Barre syndrome and hypokalemia. The pathogenesis and also the role of host and virus in dengue neuromuscular complications were not clear. In this case report, a 36 year-old female MG patient suffered from dengue infection. The MG symptoms worsen and then improved along with the course of dengue. There was a possibility that muscle weakness in this patient were related to dengue disease as the symptoms improved along with the resolving dengue, but the mechanism could be associated with virus neurotropic effect, systemic infection effect or immune mediated.