Yu Lei, Jiabin Su and Yuxiang Gu
Moyamoya disease (MMD) in adult patients is commonly accompanied by vascular cognitive impairment (VCI). The mechanism behind is still unclear and has been related to its hemodynamic disturbances. Surgical revascularization seems to be the only efficacious way to maintain the cognitive outcome, while problems such as the selection of operation indications and timing, and the long-term efficacy still need to be solved. The purpose of this article is to review the related literatures in recent years and to summarize the results in our research on the mechanism and surgical intervention of VCI in patients with MMD.