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UV-Spectrophotometric-Assisted Chemometric Methods for the Simultaneous Determination of Metformin Hydrochloride and Gliclazide in Pharmaceutical Formulations
Radhika Bhaskar, Rahul Bhaskar, Mahendra K Sagar, Vipin Saini and KM Bhat
In this study, the simultaneous determination of Metformin hydrochloride (MET) and Gliclazide (GLZ) in pharmaceuticals by chemometric approaches using UV spectrophotometry has been reported. Spectra of MET and GLZ were recorded at several concentrations within their linear ranges between wavelengths of 200 nm to 400 nm in pH 6.8 phosphate buffer. Partial Least Squares regression (PLS) and Net Aanalyte Preprocessing combined with Classical Least Square (NAP/CLS) were used for chemometric analysis of data and the parameters of the chemometric procedures were optimized. The recoveries were satisfactory and statistically comparable. The method was successfully applied to pharmaceutical formulation, tablet, with no interference with excipients as indicated by the recovery study results. The proposed methods are simple, rapid and can be easily used in the quality control of drugs as alternative analysis tools.