Jornal de Nanomedicina e Nanotecnologia

Abstrato

The Formation of Doxorubicin Loaded Targeted Nanoparticles using Nanoprecipitation, Double Emulsion and Single Emulsion for Cancer Treatment

Toyin Jibowu

Chemotherapeutic agents lead to the damage of healthy cells because they react with cells which are dividing at a high rate by inhibiting the DNA synthesis and interfering with the process of cell division. "Therapeutic drug delivery allows for an increase in the efficacy of the chemotherapeutic agent while minimizing the interaction with nontumour sites in the body by controlling the release rate of the therapeutic agent and having targeted sites on the nanoparticle which will allow the nanoparticle to release its contents at targeted sites." There are three main methods of creating nanocarriers for drug delivery that will be consider in this paper, nanoprecipitation, single emulsion and double emulsion. N Single emulsion is the formation of nanoparticles through oil in water emulsion. Another way to decrease the toxic effect of the drug loaded nanoparticle on the cells is by having specific ligands attached to the nanoparticle that specifically targets a cancer cells or have magnetic particles that one can move to the area where the tumour is located by using a magnet