Jornal de pesquisas e relatórios de tumores

Abstrato

The Effects of Quercetin on the Fluorosis Toxicity in Kidney of Mice

Ercan Karabulut*, Onder Otlu, Ahu Pakdemirli, Murat Yarım, Ayris Salt and Sena Cenesiz

There are many uses of fluorine compounds which we are exposed to in daily life unaware, have toxic effects on tissues. Demonstrating anti-oxidative effect is one of the most important biological properties of phenolic substances. It has been identified in vitro studies of antioxidant flavonoids such as quercetin that it reduces the oxidation of lowdensity lipoproteins and protects cells from toxicity. In this study we aimed to determine the effect of quercetin on the fluorosis toxicity in kidney. In the study, 40 Swiss albino male mice were used. The kidney tissues and blood samples were taken from the mice in each group. Total Oxidant Status and Total Antioxidant Status were measured by the commercially available kits. Ceruloplasmin and MDA levels are measured by chlorometric methods. Kidney tissues stained with Hematoxylin-Eosin dye and investigated under the light microscope. Histopathological changes were observed in the kidneys. Antioxidant status no statistically differences but increase with Quercetin, decreases in Fluorosis groups. In light of this study, we think that the environmental toxicities will be alleviated by taking the antioxidant molecules such as quercetin into the body.