Jornal de Nanomedicina e Nanotecnologia

Abstrato

Study on screening Vietnamese herbs with antiviral activity to create products to support treatment of some diseases caused by RNA-virus

Quang Huan Le1*, The Quan Nguyen1, Hoang Minh Duc1, Thi Tam Quyen Doan1, Thi Huyen Trang Chu2, and Thu Thao Dao2 and Thi Thanh Huong Ha3

Using information technology and traditional oriental medicine research, we have screened 5 Vietnamese herbs that contain active ingredients with antiviral effects. Andrographispaniculata, Syzygiumaromaum, Zingiber officinale Rose, Houttuyniacordata, Glycyrrhizauralensis Fisch. The active ingredients in herbs are extracted by ultrasound in a water-ethanol solvent system and made in the form of a nanometer complex, then mixed in specified proportions to form the product. The product was evaluated cytotoxicity by MTT (3-(4,5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay and evaluated the growth inhibition effect of H5N1 virus. Result: The complex of active ingredients in the composition has the nanometer size, the main size is 443 nm, the zeta potential is -11.9 mV. The inhibitory activity of the H5N1 virus was dose-dependent, and a concentration of 3 mg/mL completely inhibited the growth of the H5N1 virus in the erythrocyte agglutination test.