Jornal de pesquisa e terapia com células-tronco

Abstrato

Stimuli responsive lipid coated mesoporous silica nanoparticles for drug delivery

Muhammad Umair

Immediate relinquishment of the drug from the drug distribution carrier after cellular uptake is a sizably voluminous challenge. Premature leakage of the chemotherapeutics during circulation, causing side effects to salubrious tissue, is even more germane. Stimuli responsive drug distribution systems have addressed these issues and have become more alluring in last few years. Physical stimuli including ultrasound (US) due to its non- invasive nature are considered very safe and efficacious. Mesoporous silica nanoparticles due to their salient features are very felicitous for drug distribution to tumor cells. These features include more sizably voluminous surface area, hydrophilic and hydrophobic nature, tailorable pore size and pore volume, inner and outer surface for affixment, mechanical vigor and non-toxic nature. By cumulating distinguishing features of liposomes to mesoporous silica nanoparticles very copacetic results can be achieved. We have developed an US responsive drug distribution system where we have utilized mesoporous silica nanoparticles as a drug carrier, doxorubicin as a model drug, perfluoropentane (PFP) as an US responsive material and liposomes as gatekeeper. The relinquishment of the drug was prosperously triggered by US due to the disruption of low boiling point PFP inside pores, building up pressure and causing the immediate release. This immediate release was additionally visually examined in cell culture experiments where our system has engendered more cytotoxic effects to tumor cells as compared to non- US carriers. Lipid coating to MSNPs not only provided the gate keeping effects but additionally enhanced the cellular uptake of the carrier