Hiroshi Bando, Koji Ebe, Kazuki Sakamoto, Tomoya Ogawa, Masahiro Bando and Yoshikazu Yonei
Background: There have been discussion for years concerning Calorie Restriction (CR) and low carbohydrate diet (LCD). As to LCD, we have reported clinical experience and research for glucose variability and ketone bodies.
Case and results: The patient was 41 yo man with type 2 diabetes mellitus (T2DM). His data includes height 186 cm, BMI 31.2, fasting blood glucose 151 mg/dL, HbA1c 9.4%. He was on super LCD diet with 12% of carbohydrate, and has continued aerobics exercise and muscle training. Average glucose level on day 2,4 and 10 was 161 mg/dL, 117 mg/dL and 102 mg/dL, respectively. Body weight decreased from 107 kg to 100 kg in 4 weeks. As ketone body, 3-hydroxybutyric acid (3-OHBA) was elevated to 2350 μmol/L (-85). Lipid profiles from day 2 to day 28 showed that Triglyceride 215 to 46, HDL 32 to 44, LDL 89 to 93.
Discussion and conclusion: Authors have proposed 3 types of LCD so far, which are petit, standard and super, with 12%, 26%, 40% of carbohydrate ratio. Continuing super-LCD usually brings elevated ketone bodies and significant weight reduction. As for successful result, influenced factors would be application of super LCD, aerobics and anaerobic exercise, understanding and adequate continuation, adequate support of co-medicals.