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Pegylated PPI Dendrimer Cored with Ethylene Diamine for Prolonged Release of Prednisolone
Ramadoss Karthikeyan, Kumar PV and Koushik OS
The present study aims at exploring and developing the use of PEGylated poly(propylene imine) dendritic scaffold for the delivery of an antileukemic drug, Prednisolone. For this study, PEGylated poly(propylene imine) dendritic scaffold was synthesized and loaded with Prednisolone. Various physicochemical and physiological parameters IR, NMR, SEM, drug release, hemolytic toxicity, DSC and drug entrapment of both PEGylated and non-PEGylated systems were determined and compared. Drug-loading capacity was found to have increased with the PEGylation and reduced their hemolytic toxicity and drug release rate, so prolonged delivery of Prednisolone were found suitable with these systems.