Jornal de Nanomedicina e Nanotecnologia

Abstrato

Nanotechnology based Targeted Delivery of Drugs: Cancer Therapy

Silva Luís

Several scientific breakthrough and inventions that could militate against uncountable barriers normally experienced in traditional drugs delivery system are utilized as therapeutic candidate for the management of cancer diseases. 66It has been observed that conventional chemotherapeutics are associated with several side effects and high level of toxicity, entailing impairment of the immune system as well as having numerous detrimental effects on organ with quick penetrating cells that might be linked to the absence of solubility, nonspecific targeting, and incapability of the drug to enter the core of the tumors, which eventually lead to compromised treatment with a decrease dose and with little subsistence rate. Nanotechnology has a very great prospect with direct impact on cancerous cells as well as higher selectively with enhanced cellular uptake and drug localization. Moreover, nanoparticles could be automated for accurate identification of cancerous cells permitting selective and more precise drug delivery, which could prevent interface with the healthy cells. This chapter provides detailed information on the cell identification capability of nanomaterials with the aids of special strategies that could differentiate them from the anticancer therapies. Special highlights are provided on specific nanodrugs that are highly effective for target delivery of the active constituents against numerous cancerous cells and how they could ameliorate several side effects of unadventurous therapies.