Jornal de Carcinogênese e Mutagênese

Abstrato

NADPH: Quinone Oxidoreductase 1 (NQO1609C>T) Polymorphism and Gastric Cancer Risk: A Meta-Analysis

Manzoor Ahmad Malik, Haq S, Yetoo DM, Baba RA, Nissar S, Gull A, Malik SA and Shah ZA

Evidence is increasingly emerging about multiple roles for the NAD (P) H quinine oxidoreductase 1 (NQO1) enzyme in gastric cancer (GC). The NQO1609C>T (Pro187Ser) null polymorphism of the NQO1 gene contributes significantly to the variation in enzymatic activity across different populations. NQO1609C>T polymorphism was thoroughly investigated with respect to gastric cancer susceptibility. The results were inconsistent partly due to low sample sizes. The aim of the present work was to perform a meta-analysis to assess association for gastric cancer. Present meta-analysis involved eligible studies including 722 cases and 853 controls. Present metaanalysis found a statistically significant association between the variant T allele and overall cancer risk in the worldwide population (for the TT vs CC; co-dominant model, OR=1.568; 95%CI=1.096-2.244; P=0.014). At allele level, NQO1609C>T polymorphism was significantly correlated with increased GC risk (OR=1.302; 95%CI=1.111-1.525; P=0.001). In subgroup analysis positive association was also found for gastric cancer in recessive (OR=1.456; 95%CI=1.050-2.020; P=0.024) model. Stratified analysis revealed that this association was largely attributed to the Assian ethnicity (for the TT vs CC model, OR=1.227; 95%CI=1.022-1.473; P=0.028). Present results indicate that the 609C>T polymorphism of the NQO1 gene is an important genetic risk factor in gastric cancer.