Indexado em
  • Acesso Online à Pesquisa em Meio Ambiente (OARE)
  • Abra o Portão J
  • Genamics JournalSeek
  • JournalTOCs
  • Scimago
  • Diretório de Periódicos de Ulrich
  • Acesso à pesquisa on-line global em agricultura (AGORA)
  • Biblioteca de periódicos eletrônicos
  • Centro Internacional de Agricultura e Biociências (CABI)
  • RefSeek
  • Diretório de Indexação de Periódicos de Pesquisa (DRJI)
  • Universidade de Hamdard
  • EBSCO AZ
  • OCLC- WorldCat
  • Scholarsteer
  • Catálogo online SWB
  • Biblioteca Virtual de Biologia (vifabio)
  • publons
  • MIAR
  • Comissão de Bolsas Universitárias
  • Euro Pub
  • Google Scholar
Veja mais
Links Úteis
Compartilhe esta página
Folheto de jornal
Flyer image
Periódicos de Acesso Aberto
Veja mais

Abstrato

Molecular Characterization and Expression Pattern of a Liver-Expressed Antimicrobial Peptide 2 (LEAP-2) Gene in Yellow Catfish (Pelteobagrus fulvidraco)

Gang Ren,Wen-Ying Shen*,Wei-Fen Li,Yao-rong Zhu

Liver-expressed antimicrobial peptide 2 (LEAP-2) is a member of antimicrobial peptides, which acts as an
important component of the host innate immune system and plays a crucial role in host defense against microbial invasion. In this study, a LEAP-2 gene (PfLEAP-2) was amplified from the liver of yellow catfish (Pelteobagrus fulvidraco) by reverse transcription PCR. The length of P LEAP-2 open reading frame was 282 bp, which encode 94 amino acids (aa) including a 28-aa signal peptide, a 21-aa prodomain, and a 45-aa mature peptide. The results of tissue distribution showed that PfLEAP-2 mRNA was mainly expressed in the gill, skin, stomach, and head kidney. The significant up-regulation of PfLEAP-2 in liver after 4 hours of challenge of Edwardsiella tarda suggested, PfLEAP-2 might play an important role in the early immune defense of the yellow catfish against bacterial pathogen