Jornal de Nanomedicina e Nanotecnologia

Abstrato

Mini Review on Natural Polysaccharides Used in Vaccine by Nanoengineering

Ana Sara

The pathogenesis of about 30 viruses and bacteria is currently prevented by more than 70 approved vaccinations. However, there are still significant obstacles in this area, such as the need for more potent, non-invasive, and temperature-resistant vaccinations. Proteins, peptides, and nucleic acids are safer subunit antigens as a result of significant biotechnological advancements. Their modest immunogenicity has, however, necessitated the use of potent adjuvants that can boost the immune response. Particulate nanocarriers have great potential as immunization adjuvants. They can improve immune responses by simulating the natural infection process because of their size and structure that resemble pathogens. They can also be adapted for non-invasive mucosal administration (needle-free vaccination), and they can control the delivery of the associated antigens to a specific area and for extended periods of time. Creating space for immunization with a single dosage. Additionally, they permit the co-association of immunostimulatory molecules, which boosts the adjuvant's total capability