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Matrix metalloproteinases: a possible new marker of the effectiveness of bariatric surgery

Radu Mihail Mirica, Mihai Ionescu, Alexandra Mirica, Octav Ginghina, Razvan Iosifescu, Adrian Rosca, Laura Gaman, Bogdan Marinescu, Nicolae Iordache, Leon Zagrean

Matrix metalloproteinases (MMPs) are known ezymes involved in the modulation of extracellular matrix (ECM) and adipocyte and preadipocytes differentiation. Obesity implies a more or less rapid but generalized increase in adipose tissue (adipocyte and preadipocytes) and this proceses generate abnormal ECM metabolism.

Aim: This study purpose was to determin if we can consider MMPs as a marker of effectiveness in bariatric surgery.

Materials and methods: The experimental study used 20 obese wistar rats (10 in control group and 10 in Study group).The study group had gastric by-pass for obesity, and there were analised the pre and post operative MMP-2 and MMP-9. We compared the results in order to see if bariatric surgery modifies the MMPs status and if there is a correlation between the weight loss and the values of MMPs.

Results: The MMP-2 and MMP-9 activities were detectable, but MMP-2 activity was significantly higher than MMP-9. MMP-9 was strongly correlated with body weight parameters before surgery, as well as after significant body weight reduction as a result of bariatric surgery. There is a strong correlation between a greater weight loss and the values of MMP-2.

Conclusions: MMP-2 and MMP-9 are the two most important proteins of ECM involved in adipose tissue remodeling after bariatric surgery. Although we believe that more in-depth studies are required,

MMPs may be considered a marker of the effectiveness of bariatric surgery and weight loss.