Biologia e Medicina

Abstrato

Isolation And Studying of Specificity of Bacteriophages Binding To Murine Lung Adenocarcinoma

Mariya Borisovna Borgoyakova, Larisa Ivanovna Karpenko and Alexander Alekseevich Ilyichev

The results of affinity selection in vivo from phage peptide libraries for the identification of peptides that bind to the transplantable tumor, murine lung adenocarcinoma and hepatocarcinoma, are described in this survey. Studying the affinity of the selected phages to tumor showed that they accumulated in the tumors tens and hundreds times as much as in the control organs. Absence of specific binding of phages to tumor cells in vitro allows presuming that phage accumulation in tumors in vivo is provided by interaction of peptides exposed on the surface of virion with elements of stroma.