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Fluorinated Aromatic Amino Acids and its Therapeutic Applications
Kiran K Andra
Fluorinated amino acids play a significant role in peptides and protein studies. These are known to enhance the stability of proteins folds and serve as valuable analogues for investigation of enzyme kinetics, protein-protein and ligand-receptor interactions. Due to the unique properties of fluorine, fluorinated amino acids are used as a powerful tool to study biological process and to develop anti-cancer reagents and vaccines. Previous reviews cover synthesis and applications of fluorinated amino acids in broad range; this short review provides the importance of fluorinated aromatic amino acids and the impact of fluorine substitution in its aromatic rings that facilitate the study of structure, function and stability of therapeutic proteins and peptides which have great potential for future therapeutic applications.