Pharmaceutica Analytica Acta

Abstrato

Evaluation of Ethanolic Extract of Desmodium gyrans DC Leaves on Wound Healing Activity in Rats

Gopalakrishnan S and Rajameena R

Desmodium gyrans DC is a well-known herb for its antidote, cardiac-tonic and wound healing activities. The present study was aimed for wound healing potential of the ethanol extract of Desmodium gyrans leaves in the form of simple ointment using two types of wound models in rats, viz. excision wound and dead space wound. The results were comparable to standard drug ciphadin ointment, in terms of wound contraction, tensile strength, histopathological and hydroxy proline content. Histopathological study showed significant increase in fibroblast cells, collagen fibres and blood vessels formation. All parameters were observed significant (p<0.01) in comparison to control group.