Jornal de Carcinogênese e Mutagênese

Abstrato

Emerging Role of the Peroxisome Proliferator-Activated Receptors in Hepatocellular Carcinoma

Inés Díaz-Laviada, Guillermo Velasco, Nieves Rodríguez-Henche, Maria Salazar, Maria Cecilia Morell, Ágata Ramos-Torres and Alberto Domingo

Hepatocellular carcinoma (HCC) is the most common primary liver neoplasm and the third leading cause of cancer deaths worldwide. Conventional therapies are not generally effective for advanced HCC and therefore a great effort is needed in developing approaches to prevent or reverse the progression of HCC. There is an emerging body of evidence that the peroxisome proliferator-activated nuclear receptors (PPAR) regulate the growth and proliferation of HCC cells. Herein, we provide a brief introduction to PPAR biology and review recent discoveries highlighting the importance of PPAR signaling in the modulation of hepatocellular carcinoma development and growth.