Pharmaceutica Analytica Acta

Abstrato

Does the Zinc Neuroprotective Effectiveness of Mean Prevention of Intracellular Zinc Accumulation in Water in INDIA

Shuvam Agarwal

Zinc (Zn) plays an important role in the activity of all cells, including neurons. Both the neurotoxic and neuroprotective effects of zinc have been well established, but the exact mechanism of its dual abilities still remains unclear. The same effect may also be found in other cells, but it should be remembered that lower sensitivity to hypoxia prolongs in time the cytotoxic effect of Zn+2 excess.
It seems that the apparent dualism depends primarily on the energetic condition of the cell, and also on the efficacy of ion pumps, genetically conditioned mechanisms regulating Zn cell efflux and Zn sequestration inside the cell and also on the concentration of extracellular free Zn.