Avanços em Farmacoepidemiologia e Segurança de Medicamentos

Abstrato

Biological Therapies: Induced Autoimmune Adverse Manifestations

Alexandros A. Drosos, Eleftherios Pelechas, Paraskevi V. Voulgari

Biological therapies are increasingly used for the treatment of inflammatory arthritides and certain autoimmune rheumatic diseases. Biological agents target specific components of the immune system such as cytokines and their receptors, as well as T and B cells. Thus, the function of an intact immune system is altered and many autoimmune adverse manifestations and paradoxical reactions can take place. In this narrative mini review, we highlight the most common adverse manifestations that may develop during the use of biological therapies while treating rheumatic diseases. Under these circumstances, close follow-up and monitoring and a thorough clinical evaluation are mandatory for early recognition and treatment of these disorders.