Bioquímica e Bioquímica Analítica

Abstrato

Bio vs. Mimetics in Bioanalysis: An Editorial

Frieder W. Scheller and Aysu Yarman

Natural evolution has created biopolymers on the basis of amino acids and nucleotides showing high chemical selectivity and catalytic power. Molecular recognition by antibodies and catalytic conversion of the substrate molecules by enzymes take place in so called paratopes or catalytic centres of the macromolecule which comprise typically 10-15 amino acids. The concerted interaction between the reaction partners result in affinities down to nanomolar concentrations for the antigen binding and approaches one million turnovers per second in enzyme-catalyzed reactions.