Indexado em
- Abra o Portão J
- Genamics JournalSeek
- CiteFactor
- cosmos SE
- Scimago
- Diretório de Periódicos de Ulrich
- Biblioteca de periódicos eletrônicos
- RefSeek
- Universidade de Hamdard
- EBSCO AZ
- Diretório de Indexação de Resumos para Periódicos
- OCLC- WorldCat
- Invocação Proquest
- Scholarsteer
- ESTRADA
- Biblioteca Virtual de Biologia (vifabio)
- publons
- Fundação de Genebra para Educação e Pesquisa Médica
- Google Scholar
Links Úteis
Compartilhe esta página
Folheto de jornal
Periódicos de Acesso Aberto
- Agro e Aquicultura
- Alimentos e Nutrição
- Bioinformática e Biologia de Sistemas
- Bioquímica
- Ciência de materiais
- Ciencias ambientais
- Ciências Clínicas
- Ciências Farmacêuticas
- Ciências gerais
- Ciências Médicas
- Cuidados de enfermagem e saúde
- Engenharia
- Genética e Biologia Molecular
- Gestão de negócios
- Imunologia e Microbiologia
- Neurociência e Psicologia
- Química
Abstrato
Anti-oxidative and hepatoprotective effect of beta-carotene on acetaminophen-induced liver damage in rats
AO Morakinyo, BO Iranloye, OT Oyelowo, J Nnaji
The role of oxidative stress on the hepatic damage caused by acetaminophen (APAP) and the possible protective effects of beta-carotene supplement against this damage were investigated. The rats were randomly divided into four groups: control, APAP, beta-carotene, and APAP1beta-carotene. The control group received distilled water while APAP (750 mg/kg body weight), beta-carotene (10 mg/kg/day body weight) (BC) were administered to the other groups accordingly. The serum glutamate oxalate transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT) as well as serum alkaline phosphatase (SAP) levels of APAP group were significantly increased when compared with the control (p , 0.01). This was ameliorated by the administration of beta-carotene. The SOD, GSH, and CAT levels of the APAP groups which were significantly decreased (p , 0.001) when compared with the control. There was a boost in the antioxidant level after the application of BC. The reverse was the case in the malondialdehyde (MDA) activity. The study showed that BC will ameliorate the damaging effect of APAP on liver tissues.