Biologia e Medicina

Abstrato

Analgesic and anti-inflammatory activities of Rhynchostylis retusa

M Al-Amin, GNN Sultana, CF Hossain

The methanolic leaf extract of Rhynchostylis retusa (L.) Blume was evaluated for analgesic and anti-inflammatory activities in mice. The analgesic activity was studied using acetic acid induced writhing and the anti-inflammatory activity was studied on carrageenan and formaldehyde induced paw edema. It was observed that the extract showed 28.84% and 35.81% inhibition of acetic acid induced writhing at doses of 200 mg/kg and 400 mg/kg, respectively, 7.80%, 8.67% and 14.32% mean inhibition of carrageenan induced paw edema at doses of 100 mg/kg, 200 mg/kg and 400 mg/kg, respectively, and significant (p < 0.01, p < 0.001) anti-inflammatory activity of formaldehyde induced mice paw edema at doses of 200 mg/kg and 400 mg/kg. It can be concluded that the extract exerts dose dependent analgesic and anti-inflammatory activities.