Jornal de Bioequivalência e Biodisponibilidade

Abstrato

An Overview of Analytical Determination of Captopril in Active Pharmaceutical Ingredients (API) Formulation and Biological Fluids

Naveed S

Present review article determine the analytical methods for the quantitative determinations of Captopril (ACE Inhibitor) by one of the spectroscopic technique (UV spectrophotometery) and separation technique such as High- Performance Liquid chromatography (HPLC). The clinical and pharmaceutical analysis of captopril requires effective analytical procedures for quality control, Pharmaceuticals dosage formulations and human serum. An extensive survey of the research articles published in various pharmaceutical, clinical and analytical chemistry related journals has been compiled in this paper. A synopsis of reported spectrophotometer and high-performance liquid chromatographic methods for captopril are integrated. This appraisal illustrate that majority of the HPLC methods reviewed are based on the quantitative analysis of drug in active Pharmaceutical ingredients (API) biological fluids such as serum and plasma and they are appropriate for therapeutic drug monitoring , pharmacokinetic purpose.