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Allogeneic Mesenchymal Stem Cells Infusion to an ALS Patient Proved to be Safe and Capable to Initiate Clinical Recuperation: Review

J.J. Minguell , C. Allers , J. A. Jones , S.S. Ganji

No cure has been found for Amyotrophic Lateral Sclerosis (ALS) despite several studies using drugs or related compounds. Background: Cellular, molecular and preclinical studies have suggested that the use of Mesenchymal Stem Cells (MSC) may represent a therapeutic option for ALS treatment. MSC exhibit a capability for self-renewal, differentiation (mesoderm and neuroectoderm phenotypes) and production/release of neuroprotective mediators. All these attributes epitomize an option for using MSC in ALS. Materials and Methods: Minimally manipulated ex vivo expanded allogeneic bone marrow-derived MSC (0.6 x 106 MSC/kg body weight) were intrathecally infused to an ALS patient. Quantitative clinical assessments as well as vital signs, access site and neurological clinical assessment were monitored after cell infusion.

Isenção de responsabilidade: Este resumo foi traduzido usando ferramentas de inteligência artificial e ainda não foi revisado ou verificado