Indexado em
- Abra o Portão J
- Genamics JournalSeek
- Chaves Acadêmicas
- JournalTOCs
- Infraestrutura Nacional de Conhecimento da China (CNKI)
- Diretório de Periódicos de Ulrich
- RefSeek
- Universidade de Hamdard
- EBSCO AZ
- Diretório de Indexação de Resumos para Periódicos
- OCLC- WorldCat
- publons
- Fundação de Genebra para Educação e Pesquisa Médica
- Euro Pub
- Google Scholar
Links Úteis
Compartilhe esta página
Folheto de jornal
Periódicos de Acesso Aberto
- Agro e Aquicultura
- Alimentos e Nutrição
- Bioinformática e Biologia de Sistemas
- Bioquímica
- Ciência de materiais
- Ciencias ambientais
- Ciências Clínicas
- Ciências Farmacêuticas
- Ciências gerais
- Ciências Médicas
- Cuidados de enfermagem e saúde
- Engenharia
- Genética e Biologia Molecular
- Gestão de negócios
- Imunologia e Microbiologia
- Neurociência e Psicologia
- Química
Abstrato
A Population of Human Mesenchymal Stem Cells Specific to the Fetal Liver Development
Wenwei Zhang, Zahia Hamidouche, Guillaume Pourcher, Varvara Gribova, Farhad Haghighi, Jean-Jacques Candelier, Pierre Charbord and Anne Dubart-Kupperschmitt
Mesenchymal Stem Cells (MSCs) with osteoblastic/chondrocytic potential have been detected in different anatomical sites including the Fetal Liver (FL). The puzzling presence of such cells in FL led us to investigate whether they displayed additional differentiation competence compatible with their location at this developmental stage. This study has resulted in the successful isolation of a population of clonogenic cells from 11-12 gestational week human fetal livers that spontaneously differentiated into vascular smooth muscle cells during the proliferative phase. The cells were also able to differentiate into adipocytes, osteoblasts and chondrocytes, but only when submitted to specific culture conditions. Moreover, the isolated population expressed hepatocytic transcription factors. The analysis of FL sections suggested that the clones generated in culture were derived from a subset of nestin+, vimentin+ and alpha- SM actin+ pericytes. The FL specification of the MSCs described here is in agreement with the known plasticity of the mesenchyme.